Most serums send the signal. This one sends the signal and the fuel.
Melao Cross-Border Spot Pdrn Hyaluronic Acid Moisturizing Cream
Glasselle is a daily regenerative cream built around two things most PDRN creams only do one of: triggering your skin's repair process with PDRN, and giving it the cellular energy to actually follow through with NAD+. Firmer, smoother, more even skin — starting week one.
- PDRN signals repair. NAD+ powers it. Most creams only do one.
- Visibly firms and smooths skin in as little as 2 weeks
- Evens skin tone and restores natural radiance
- Absorbs completely — no residue, no pilling under makeup
- 60-day money-back guarantee, no questions asked
60-Day Money-Back Guarantee
Free Shipping Included
Have a question? Email us at support@glasselle.com and we'll write back within 24 hours
See it in action
Your PDRN serum is sending a message your skin doesn't have the energy to answer
That's why it stopped working. Here's the fix.
Here is something the PDRN category has been quietly avoiding. The science behind PDRN is real. It activates receptors in your skin that trigger collagen production and cellular repair. That part is true.
What nobody mentions is what happens next. Your skin gets the signal. And then it needs energy to act on it. Cellular energy. The kind that comes from NAD+, a molecule your body produces less of with every passing year. Without it, the repair signal fires and nothing happens. Your skin heard the message. It just didn't have the fuel to respond.
Glasselle is the first daily cream we know of that pairs PDRN with NAD+ in the same formula. Not as a marketing line. As a mechanism. PDRN tells your skin to repair. NAD+ makes sure it actually can. The result is regeneration that compounds — not just the feeling of a good skin day that fades by tomorrow.
The repair signal
The repair signal
PDRN activates adenosine receptors in your skin cells. When those receptors fire, your skin produces more collagen and begins repairing itself the same way it heals a wound. This is not a surface treatment. It is a cellular instruction.
The fuel most formulas forget
Cellular repair runs on NAD+. Over time, NAD+ levels in your skin drop measurably — reducing your skin's ability to repair itself. Most PDRN creams send the repair signal and stop there. Glasselle includes NAD+ so your skin has the energy to actually follow through. Almost no daily cream does this.
The anti-wrinkle ingredient hiding in plain sight
Adenosine is in this formula and nobody talks about it. It has its own clinical track record for reducing the appearance of fine lines and improving skin elasticity in cream form, independent of PDRN. Most brands bury it at the bottom of the label. We put it in the formula because it works.
Hydration that actually stays
Standard hyaluronic acid works on the surface. In dry environments, it can pull moisture upward from deeper skin layers and release it into the air. That is why your skin is dry by noon even when you applied something this morning. Glasselle pairs its hydration complex with jojoba oil and glycerin to lock moisture in so it stays where it belongs.
What Customers Say
What customers say after using it
J
Jennifer K.
- Stopped wearing foundation completely
Reviewed
in the
United States
on
May 12, 2026
I've been using it for two weeks and have noticed a clear improvement in my 42-year-old skin. You absolutely get the glass skin effect — but I'm also noticing an improvement in my skin texture and moisture around the clock. I've stopped wearing any foundation.
87
people found this helpful
|
S
Samantha T.
- My skin looks younger, smoother
Reviewed
in the
United States
on
April 28, 2026
My face looks younger, smoother. I can go without makeup and feel comfortable and confident in my own skin. It's non-greasy and lightweight. I will be purchasing again and again.
64
people found this helpful
|
M
Maria P.
- My post-microneedling holy grail
Reviewed
in the
United States
on
June 3, 2026
I bought this for post-microneedling — I've been hooked and used it ever since. This bottle lasted me 4 to 5 months. I use it every day. I absolutely love this product.
51
people found this helpful
|
J
Julia R.
- Finally, something that doesn't break me out
Reviewed
in the
United States
on
March 19, 2026
Holy grail for sensitive, acne-prone skin. This has been one of the few moisturizers that consistently works well for me without causing issues. I will probably continue repurchasing indefinitely.
73
people found this helpful
|
What's Inside & Why It Matters
PDRN
PDRN Activates the repair receptors in your skin cells to trigger collagen production and tissue renewal. The signal that tells your skin to start fixing itself.
Activates cellular repair
Stimulates collagen production
Compounds with consistent use
NAD+
NAD+ The cellular energy molecule that powers your skin's repair response. Declines naturally over time. Almost never included in a daily cream. Glasselle puts it back so the repair signal PDRN sends actually gets answered.
Powers skin repair
Declines with age
Rarely found in daily skincare
Adenosine
Clinically studied in cream form for reducing the appearance of fine lines and improving elasticity. Works independently of PDRN. A proven anti-wrinkle active most brands treat as an afterthought.
Reduces fine line appearance
Improves elasticity
Clinically studied in cream form
Niacinamide
One of the most studied ingredients in skincare. Visibly evens skin tone, minimizes the look of pores, and converts to NAD+ inside your skin cells for an additional boost to the repair cycle.
Evens and brightens tone
Minimizes pore appearance
Converts to NAD+ in skin
What to Expect
We're not going to promise overnight results. Here's what actually happens.
Instant Hydration
Skin feels softer and more comfortable from the very first application. The hydration complex absorbs immediately and gets to work.
Smoother Texture
Within the first week, most people notice their skin feels smoother and stays hydrated longer. Niacinamide starts visibly improving tone and pore appearance.
Visible Repair
This is when PDRN and Adenosine start showing at the surface. Skin looks firmer. Fine lines soften. Most customers stop reaching for foundation — not because they tried to, but because they stopped needing it.
The Compliments Start
With consistent use, the repair compounds. People around you start noticing. They start asking what you have been doing differently.
Instant Hydration
Skin feels softer and more comfortable from the very first application. The hydration complex absorbs immediately and gets to work.
Smoother Texture
Within the first week, most people notice their skin feels smoother and stays hydrated longer. Niacinamide starts visibly improving tone and pore appearance.
Visible Repair
This is when PDRN and Adenosine start showing at the surface. Skin looks firmer. Fine lines soften. Most customers stop reaching for foundation — not because they tried to, but because they stopped needing it.
The Compliments Start
With consistent use, the repair compounds. People around you start noticing. They start asking what you have been doing differently.
How is this different from the PDRN serum I already tried?
+
Most PDRN creams send the repair signal and stop there. Glasselle also includes NAD+, the cellular energy molecule your skin needs to actually act on that signal. Without it, the repair process fires but your skin doesn't have the fuel to follow through. That is the gap most formulas leave open.
I have sensitive or acne-prone skin. Will this work for me?
+
Yes. The formula includes a botanical calming complex specifically chosen for reactive skin. It does not use centella or cica. If you have a known sensitivity to Niacinamide, do a quick patch test before your first full application.
Does topical PDRN actually absorb into the skin?
+
This is the right question and we are glad you are asking it. PDRN absorption in topical form is an active area of research. What we know is that the Adenosine and NAD+ in this formula have independent clinical evidence for working in cream form — making them the substantiated workhorses of the formula regardless of PDRN penetration depth.
Can I use this alongside my other skincare?
+
Yes. Apply Glasselle as the last step in your skincare routine before sunscreen and makeup. It layers seamlessly without pilling or interference.
How long until I see real results?
+
Hydration is immediate. Smoother texture typically shows within the first week. Visibly firmer skin and softer fine lines usually appear between weeks two and four as the repair compounds over time.
What is Glasselle?
+
We're a small team in Orlando, FL. We built Glasselle because we wanted a PDRN cream that didn't cost $200. Every order comes with real support. Email us at support@glasselle.com and a real person will write back.
Backed by Research
PDRN and cellular repair
Research confirms PDRN activates A2A adenosine receptors in skin cells, triggering collagen synthesis and tissue regeneration — the same mechanism used in wound healing and aesthetic medicine for decades.
NAD+ and skin aging
Clinical studies show NAD+ levels in skin decline significantly with age, reducing the cell's capacity to repair damage. Topical NAD+ precursors have been shown to measurably raise NAD+ levels and increase dermal thickness in human studies.
Adenosine in cream form
Unlike some regenerative actives, Adenosine has specific clinical evidence for working in cream form — randomized double-blind studies showed statistically significant improvement in wrinkling, elasticity, and hydration after 3 to 8 weeks of twice-daily use.
Why single-ingredient hydration fails
Research shows standard hyaluronic acid works only at the skin's surface and can draw moisture upward in dry environments. Multi-ingredient hydration systems produce more consistent, lasting results.
How to Use
1. Cleanse your face
Start with a clean, dry face. Remove makeup or sunscreen first.
2. Apply other serums first
If you use other serums, apply those first. Let them soak in.
3. Apply a pea-sized amount
Use a small amount. Gently pat it into your skin. Don't rub it in.
4. Follow with sunscreen
In the morning, finish with sunscreen. This protects your skin and helps PDRN work better.
Everything You're Getting
One tube of Glasselle PDRN Regenerative Cream. Free shipping on every order. A 60-day money-back guarantee, no questions asked. The only daily cream we know of that pairs PDRN with NAD+ in a single formula — without the clinic price tag.
What's Included
- One tube of Glasselle PDRN Regenerative Cream
- Free shipping on every order
- 60-day money-back guarantee
- PDRN + NAD+ + Adenosine in one daily cream
